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Performance Qualification Protocol for Compression Machine

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The principle of compression machine is to compress the Lubricated granules into tablets within the tablet specification limit and at a specified speed.

This machine can be used to compress blended granules into tablets of desired hardness so as to achieve post compression tests such as Disintegration time, Friability, thickness, hardness and weight variation within permissible limit.

The purpose of this protocol is to verify that the equipment produces the desired output. Performance qualification of the equipment is planned after the successful completion of the installation and operational qualification.

The performance of the compression machine is verified by charging the hopper with the lubricated blend and verification of physical and chemical parameters of the tablets.

The compressions of the tablets are challenged by analyzing the compressed tablets collected at different speed and varying other parameters.

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