- VIBRO SIFTER (DQ) COMPILED DOC
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A vibro sifter (vibro separator / gyratory sifter) is a GMP equipment used in pharma to screen, grade, and de-lump powders or granules by passing material through one or more mesh screens using controlled vibration. Its main purpose is to ensure uniform particle size distribution, remove foreign particles/oversize lumps, and improve downstream performance in blending, granulation, compression, capsule filling, and coating.
Principle: An electric motor with eccentric weights generates multi-directional vibrations (vertical + horizontal). This creates a spiral movement of material across the screen. Fine particles pass through the mesh; oversize is discharged separately.
Typical construction/features (pharma):
- SS316 contact parts, polished finish, crevice-free design
- Screen frame(s) with tensioned meshes (single or multi-deck)
- Top cover and dust-tight clamps; optional silicone gaskets
- Inlet hopper and outlet spouts (undersize/oversize)
- Vibration motor (sometimes with VFD for speed control)
- Optional magnet trap, sieve integrity ring, CIP/WIP spray balls, explosion-proof motor for solvents/dust risk
Operation steps: verify sieve integrity → assemble and clamp → start vibration → feed material at controlled rate → collect screened output → stop and de-dust → dismantle and clean.
Critical process parameters: mesh size, screen condition/tension, vibration amplitude/speed, feed rate, material moisture, residence time, and loading pattern. Overloading causes blinding and poor separation.
GMP/RBI focus points: line clearance, correct mesh identification, sieve integrity checks (no tears), control of metal contamination, containment/dusting, cleaning validation (especially for potent products), and preventive maintenance (motor bearings, clamps, gaskets).
Common issues: screen blinding (high moisture/fines), excessive noise (loose clamps), poor yield (wrong mesh or low amplitude), and cross-contamination (inadequate cleaning or worn gaskets).